Research
A brief description of research projects currently in progress within the department.
Prostate Cancer
- ProtecT. A multicentre trial, funded by NHS R&D, to screen 125,000 men for prostate cancer with follow-up for 10 to 15 years
- PROMPT. A collaborative research program looking at genomic studies of prostate cancer to investigate new treatments for men with relapsing disease
- A randomized, double-blind, placebo-controlled trial of oral sodium clodronate in locally-advanced prostate cancer (MRC PRO4 trial)
- A randomized, double-blind, placebo-controlled trial of adjuvant sodium clodronate in patients commencing or responding to hormone therapy for metastatic prostate cancer (MRC PRO5 trial)
- A randomized trial of hormone therapy plus radical radiotherapy versus hormone therapy alone in non-metastatic prostate cancer (MRC PRO7 trial)
Urothelial Cancer
- Translational studies of MCM5 in bladder and prostate cancer (with Gareth Williams)
- A multicentre, prospective, randomized study of the value of a single dose of intravesical Mitomycin in preventing the development of bladder tumours following nephroureterectomy for transitional cell carcinoma of the upper urinary tract (ODMIT C trial)
- Tissue surplus to diagnostic requirements is being banked for molecular & genetic studies of urological malignancy. In particular, using array comparative genomic hybridization techniques, our intention is to:
- identify differences in DNA copy number & RNA expression
- evaluate the role of lymphovascular invasion, lymphangiogenesis & angiogenesis
- characterize the prognostic features of cancer related to disease severity & dissemination
Overactive Bladder
- A 12 week, randomized, double-blind, placebo controlled, parallel group, multicentre study to evaluate the efficacy, safety and tolerability of a compound in patients aged >65 years with overactive bladder (Protocol CDAR328A2409)
- A double-blind, randomized, placebo-controlled, parallel group of cannabis-based medicine extract (CBME) in patients suffering detrusor overactivity associated with multiple sclerosis
Stress Incontinence
- The safety and effectiveness of Duloxetin compared with placebo and its long-term safety and efficacy in predominant stress incontinence
