Department of Urology

David Neal  FMedSci MS FRCS

David Neal

Professor of Surgical Oncology
Clinical Director

Direct: +44 (0)1223 331940  email

NHS Secretary: +44 (0)1223 586819  email

Private Secretary: +44 (0)1223 586819 (Hilary)

Special Interests: Prostate cancer, bladder cancer, advanced testis & renal cancer

For details of all publications, please use MedLine for access. David Neal's publications have a citation rate of 18.3 per article and have been quoted over 7000 times (with an average citation rate of 500 per year).

Key Publications
Establishing a robotic prostatectomy programme; the impact of mentoring using a structured approach
Kaul SA, Peabody JA, Shah N, Neal D
British Journal of Urology International (2006), 97, 1143-1144

Epidermal growth factor receptors are present in human bladder cancer: a comparison of invasive and superficial tumours
Neal DE, Marsh C, Bennett MK, Abel PD, Hall RR, Sainsbury JRC, Harris AL
Lancet (1985), i, 366-268.

The epidermal growth factor receptor and the prognosis of bladder cancer
Neal DE, Sharples L, Smith K, Fenelly JA, Hall RR, Harris AL
Cancer (199065, 1619-1625

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.
Sigalas I, Cakvert AH, Anderson JJ, Neal DE, Lunec J
Nature Medicine (1996), 2, 912-917

Expression of c-erbB-2 protein product in bladder cancer
Wright C, Mellon K, Neal DE, Johnston P, Corbett IP, Horne CHW
British Journal of Cancer (1990), 62, 764-765

Evaluation of epidermal growth factor receptors in bladder tumours
Berger MS, Greenfield C, Gullick WJ, Haley J, Downward J, Neal DE, Harris AL, Waterfield MD
British Journal of Cancer (1987), 56, 533-537

Outcome of elective prostatectomy
Neal DE, Ramsden PD, Sharples L, Smith A, Powell PH, Styles RA, Webb RJ
British Medical Journal (1989), 299, 762-767

p53, c-erbB-2 and the epidermal growth factor receptor in the benign and malignant prostate
Mellon K, Thompson S, Charlton RG, Marsh C, Robinson M, Lane DP, Wilson Horne CH, Harris AL, Neal DE
Journal of Urology (1992), 147, 496-499

Tip60 is a nuclear hormone receptor co-activator
Brady ME, Ozanne DM, Gaughan L, Waite I, Cook S, Neal DE, Robson CN
J Biol Chem (1999), 274, 17599-17604

CD133, a novel marker for human prostatic epithelial stem cells.
Richardson GD, Robson CN, Lang SH, Neal DE, Maitland NJ, Collins AT
J Cell Science (2004,) 117, 3539-3545

Bladder function in healthy volunteers: ambulatory monitoring and conventional urodynamic studies
Robertson AJ, Griffiths CJ, Ramsden PD, Neal DE
British Journal of Urology (1994), 73, 242-249

Over-expression of fibroblast growth factor-8 in human prostate cancer
Leung HY, Dickson C, Robson CN, Neal DE
Oncogene (1996), 12, 1833-1835

FGF8 over-expression in prostate cancer IS associated with decreased patient survival and persists in androgen independent disease
Dorkin TJ, Robonson MC, Marsh C, Bjartell A, Neal DE, Leung HY
Oncogene (1999), 18, 2755-2761

Sexual dysfunction in men after treatment for lower urinary tract symptoms: evidence from randomised controlled trial
Brooks ST, Donovan JL, Peters TJ, Abrams P, Neal DE
British Medical Journal (2002), 324, 1059-1061

Tip60 and HDAC1 regulate androgen receptor activity through changes to the acetylation status of the receptor
Gaughan L, Logan IR, Cook S, Neal DE, Robson CN
J Biol Chem (2002), 277, 25904-25913

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors
Mills IG, Gaughan L, Ronson C, Ross T, McCracken S, Kelly JD, Neal DE
J Cell Biol (2005), 170, 191-200

New androgen receptor genomic targets show an interaction with the ETS1 transcription factor
Massie CE, Adryan B, Barbosa-Morais NL, Lynch AG, Tran MG, Neal DE, Mills IG
EMBO Reports (2007), 8, 871-878

Identification of multiple novel prostate cancer susceptibility loci by a genome-wide association study
Eeles RA, Kote-Jarai Z, Giles GG, Neal DE et al
Nature Genetics (2008) in press

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All Consultants:
Tevita 'Aho,  Andrew Doble,  Vincent Gnanapragasam,  Yasir Hassanein,  Christof Kastner,  John McLoughlin,  David Neal,  Frank O'Brien,  Nimish Shah,  Nikesh Thiruchelvam,  Bill Turner,  Oliver Wiseman

All Nursing Staff:
Shirley Bane,  Gillian Basnett,  Jo Burge,  Wendy Campbell,  Nicola Cheale,  Carol Edmunds,  Indu Francis,  Sarah Harris,  Claire Johnston,  Sue Norman,  Sandra Siddle,  Sara Stearn,  Mark Wynn

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Case of the Month

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A 78 year old man presents with recurrent urinary tract infections and more recently, passed air and faeces in his urine.

  1. What abnormality does this CT scan show?
  2. What investigations are usually performed?
  3. What are common causes?
  4. How are they usually managed?

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From the Glossary

Haematospermia:

Blood in the semen during ejaculation

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